These substances are sometimes referred to as “downers” as they tend to slow brain activity and heart rate, putting the consumer in a more relaxed state. These substances are habit-forming. They can also be dangerous as if they are taken in exaggerated quantities or mixed with other substances (in particular An organic compound used in many products, most notably intoxicating drinks. Alcohol addiction is known as alcoholism. The first 12-step program was devised to deal with that malady. More), which can cause death.